7xxi: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~7xxi is ON HOLD~~

==Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7xxi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XXI FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6AD:2-(METHYLSULFANYL)ADENOSINE+5-(TRIHYDROGEN+DIPHOSPHATE)'>6AD</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xxi OCA], [https://pdbe.org/7xxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xxi RCSB], [https://www.ebi.ac.uk/pdbsum/7xxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xxi ProSAT]</span></td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Han S]]

[[Category: Li B]]

[[Category: Tan Q]]

[[Category: Wu B]]

[[Category: Zhao Q]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7xxi is ON HOLD
+==Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi==
+<StructureSection load='7xxi' size='340' side='right'caption='[[7xxi]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7xxi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XXI FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6AD:2-(METHYLSULFANYL)ADENOSINE+5-(TRIHYDROGEN+DIPHOSPHATE)'>6AD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xxi OCA], [https://pdbe.org/7xxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xxi RCSB], [https://www.ebi.ac.uk/pdbsum/7xxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xxi ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Han S]]
+[[Category: Li B]]
+[[Category: Tan Q]]
+[[Category: Wu B]]
+[[Category: Zhao Q]]