8srz: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8srz is ~~ON HOLD until Paper Publication~~

==Structure of a bacterial death-like domain from Lysobacter enzymogenes==

~~Authors~~: ~~Johnson~~, A.G., ~~Kranzusch~~, P.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[8srz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysobacter_enzymogenes Lysobacter enzymogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SRZ FirstGlance]. <br>

~~Description~~: ~~Structure of~~ a ~~bacterial~~ death-~~like domain from Lysobacter enzymogenes~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8srz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8srz OCA], [https://pdbe.org/8srz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8srz RCSB], [https://www.ebi.ac.uk/pdbsum/8srz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8srz ProSAT]</span></td></tr>

[[Category: ~~Unreleased~~ Structures]]

</table>

[[Category: ~~Kranzusch, P.J~~]]

== Function ==

[[Category: Johnson~~, A.G~~]]

[https://www.uniprot.org/uniprot/PROT2_LYSEN PROT2_LYSEN] Possibly a dedicated protease for substrate gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death. Involved in defense against bacteriophages. When this probable 4 gene operon (bGSDM-FE772_23060-FE772_23065-FE772_23070) is inserted into E.coli it provides nearly 100-fold protection against phages T5 and T6 and about 8-fold against phage T4. The operon without bGSDM no longer protects against phage.<ref>PMID:35025633</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Lysobacter enzymogenes]]

[[Category: Johnson AG]]

[[Category: Kranzusch PJ]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8srz is ON HOLD  until Paper Publication
+==Structure of a bacterial death-like domain from Lysobacter enzymogenes==
+<StructureSection load='8srz' size='340' side='right'caption='[[8srz]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
-Authors: Johnson, A.G., Kranzusch, P.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8srz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysobacter_enzymogenes Lysobacter enzymogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SRZ FirstGlance]. <br>
-Description: Structure of a bacterial death-like domain from Lysobacter enzymogenes
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8srz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8srz OCA], [https://pdbe.org/8srz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8srz RCSB], [https://www.ebi.ac.uk/pdbsum/8srz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8srz ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Kranzusch, P.J]]
+== Function ==
-[[Category: Johnson, A.G]]
+[https://www.uniprot.org/uniprot/PROT2_LYSEN PROT2_LYSEN] Possibly a dedicated protease for substrate gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death. Involved in defense against bacteriophages. When this probable 4 gene operon (bGSDM-FE772_23060-FE772_23065-FE772_23070) is inserted into E.coli it provides nearly 100-fold protection against phages T5 and T6 and about 8-fold against phage T4. The operon without bGSDM no longer protects against phage.<ref>PMID:35025633</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Lysobacter enzymogenes]]
+[[Category: Johnson AG]]
+[[Category: Kranzusch PJ]]