5bqd: Difference between revisions

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<StructureSection load='5bqd' size='340' side='right'caption='[[5bqd]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
<StructureSection load='5bqd' size='340' side='right'caption='[[5bqd]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5bqd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQD FirstGlance]. <br>
<table><tr><td colspan='2'>[[5bqd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BQD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqd OCA], [http://pdbe.org/5bqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bqd RCSB], [http://www.ebi.ac.uk/pdbsum/5bqd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqd OCA], [https://pdbe.org/5bqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bqd RCSB], [https://www.ebi.ac.uk/pdbsum/5bqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqd ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN]] Holt-Oram syndrome. The disease is caused by mutations affecting the gene represented in this entry.  Defects in TBX5 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref>
[https://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN] Holt-Oram syndrome. The disease is caused by mutations affecting the gene represented in this entry.  Defects in TBX5 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN]] DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref> <ref>PMID:8988164</ref>
[https://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN] DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref> <ref>PMID:8988164</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gopal, S]]
[[Category: Gopal S]]
[[Category: Kasahara, H]]
[[Category: Kasahara H]]
[[Category: Nam, H J]]
[[Category: Nam HJ]]
[[Category: Patel, A]]
[[Category: Patel A]]
[[Category: Pradhan, L]]
[[Category: Pradhan L]]
[[Category: Cardiac]]
[[Category: Chd]]
[[Category: Dna binding]]
[[Category: Nkx]]
[[Category: Tbx]]
[[Category: Transcription]]
[[Category: Transcription factor]]