5bvi: Difference between revisions

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<StructureSection load='5bvi' size='340' side='right'caption='[[5bvi]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5bvi' size='340' side='right'caption='[[5bvi]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5bvi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVI FirstGlance]. <br>
<table><tr><td colspan='2'>[[5bvi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BVI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Irf4, mCG_4922 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvi OCA], [https://pdbe.org/5bvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bvi RCSB], [https://www.ebi.ac.uk/pdbsum/5bvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bvi OCA], [http://pdbe.org/5bvi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bvi RCSB], [http://www.ebi.ac.uk/pdbsum/5bvi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bvi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRF4_MOUSE IRF4_MOUSE] Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.<ref>PMID:22983707</ref> <ref>PMID:22992523</ref> <ref>PMID:22992524</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Escalate, C R]]
[[Category: Escalate CR]]
[[Category: Remesh, S G]]
[[Category: Remesh SG]]
[[Category: Interferon regulatory factor]]
[[Category: Transcription]]
[[Category: Transcription activation/protein-dna interaction]]
Retrieved from "https://proteopedia.org/5bvi"