5c5b: Difference between revisions

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<StructureSection load='5c5b' size='340' side='right'caption='[[5c5b]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='5c5b' size='340' side='right'caption='[[5c5b]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5c5b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5B FirstGlance]. <br>
<table><tr><td colspan='2'>[[5c5b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C5B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APPL1, APPL, DIP13A, KIAA1428 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), APPL2, DIP13B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5b OCA], [https://pdbe.org/5c5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c5b RCSB], [https://www.ebi.ac.uk/pdbsum/5c5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5b OCA], [http://pdbe.org/5c5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5b RCSB], [http://www.ebi.ac.uk/pdbsum/5c5b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5b ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/DP13B_HUMAN DP13B_HUMAN]] A chromosomal aberration involving APPL2/DIP13B is found in patients with chromosome 22q13.3 deletion syndrome. Translocation t(12;22)(q24.1;q13.3) with SHANK3/PSAP2.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref> [[http://www.uniprot.org/uniprot/DP13B_HUMAN DP13B_HUMAN]] Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:15016378</ref> 
[https://www.uniprot.org/uniprot/DP13A_HUMAN DP13A_HUMAN] Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.<ref>PMID:10490823</ref> <ref>PMID:15016378</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen, B]]
[[Category: Chen B]]
[[Category: Chen, Y J]]
[[Category: Chen YJ]]
[[Category: Heterodimer]]
[[Category: Protein transport]]
Retrieved from "https://proteopedia.org/5c5b"