7yi1: Difference between revisions
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==Cryo-EM structure of Eaf3 CHD bound to H3K36me3 nucleosome== | |||
<StructureSection load='7yi1' size='340' side='right'caption='[[7yi1]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7yi1]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YI1 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yi1 OCA], [https://pdbe.org/7yi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yi1 RCSB], [https://www.ebi.ac.uk/pdbsum/7yi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yi1 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Guan HP]] | |||
[[Category: Li HT]] | |||
[[Category: Wang P]] | |||
[[Category: Yan CY]] | |||
Revision as of 08:12, 14 June 2023
Cryo-EM structure of Eaf3 CHD bound to H3K36me3 nucleosome
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