1p9j: Difference between revisions

Line 1:

==Solution structure and dynamics of the EGF/TGF-alpha chimera T1E==

== Structural highlights ==

<table><tr><td colspan='2'>[[1p9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9J OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1P9J FirstGlance].

<table><tr><td colspan='2'>[[1p9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9J OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1P9J FirstGlance].

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">TGF-alpha and EGF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1p9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9j OCA], [https://pdbe.org/1p9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9j RCSB], [https://www.ebi.ac.uk/pdbsum/1p9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9j ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1p9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9j OCA], [https://pdbe.org/1p9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9j RCSB], [https://www.ebi.ac.uk/pdbsum/1p9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9j ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/EGF_HUMAN EGF_HUMAN] Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:[https://omim.org/entry/611718 611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.<ref>PMID:17671655</ref>

== Function ==

[[https://www.uniprot.org/uniprot/~~TGFA_HUMAN TGFA_HUMAN~~]~~] TGF alpha is a mitogenic polypeptide~~ that ~~is able to bind to~~ the ~~EGF receptor/~~EGFR and ~~to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar~~.

[https://www.uniprot.org/uniprot/EGF_HUMAN EGF_HUMAN] EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.<ref>PMID:17671655</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

Line 35:

Line 36:

__TOC__

</StructureSection>

[[Category: ~~Human~~]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

~~[[Category: Ingen, H Van]]~~

[[Category: Stortelers C]]

~~[[Category: Leeuwen, J E.Van]]~~

[[Category: Van Ingen H]]

[[Category: Stortelers, C]]

[[Category: Van Leeuwen JE]]

[[Category: ~~Vuister, G W~~]]

[[Category: Van Zoelen EJ]]

[[Category: ~~Walma, T]]~~

[[Category: Vuister GW]]

~~[[Category: Wingens, M~~]]

[[Category: Walma T]]

[[Category: Zoelen~~, E J.Van~~]]

[[Category: Wingens M]]

[[Category: ~~Chimera~~]]

[[Category: ~~Egf~~]]

[[Category: ~~Erbb1]]~~

~~[[Category: Erbb3]]~~

~~[[Category: Hormone-growth factor complex]]~~

~~[[Category: Tgf-alpha~~]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
 ==Solution structure and dynamics of the EGF/TGF-alpha chimera T1E==
-<StructureSection load='1p9j' size='340' side='right'caption='[[1p9j]], [[NMR_Ensembles_of_Models | 36 NMR models]]' scene=''>
+<StructureSection load='1p9j' size='340' side='right'caption='[[1p9j]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1p9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9J FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1p9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9J FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TGF-alpha and EGF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9j OCA], [https://pdbe.org/1p9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9j RCSB], [https://www.ebi.ac.uk/pdbsum/1p9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9j ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9j OCA], [https://pdbe.org/1p9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9j RCSB], [https://www.ebi.ac.uk/pdbsum/1p9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9j ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/EGF_HUMAN EGF_HUMAN] Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:[https://omim.org/entry/611718 611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.<ref>PMID:17671655</ref>
 == Function ==
-[[https://www.uniprot.org/uniprot/TGFA_HUMAN TGFA_HUMAN]] TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
+[https://www.uniprot.org/uniprot/EGF_HUMAN EGF_HUMAN] EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.<ref>PMID:17671655</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 35: / Line 36: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Ingen, H Van]]
+[[Category: Stortelers C]]
-[[Category: Leeuwen, J E.Van]]
+[[Category: Van Ingen H]]
-[[Category: Stortelers, C]]
+[[Category: Van Leeuwen JE]]
-[[Category: Vuister, G W]]
+[[Category: Van Zoelen EJ]]
-[[Category: Walma, T]]
+[[Category: Vuister GW]]
-[[Category: Wingens, M]]
+[[Category: Walma T]]
-[[Category: Zoelen, E J.Van]]
+[[Category: Wingens M]]
-[[Category: Chimera]]
-[[Category: Egf]]
-[[Category: Erbb1]]
-[[Category: Erbb3]]
-[[Category: Hormone-growth factor complex]]
-[[Category: Tgf-alpha]]