1l3a: Difference between revisions
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'''Structure of the plant transcriptional regulator PBF-2''' | '''Structure of the plant transcriptional regulator PBF-2''' | ||
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[[Category: Desveaux, D.]] | [[Category: Desveaux, D.]] | ||
[[Category: Sygusch, J.]] | [[Category: Sygusch, J.]] | ||
[[Category: | [[Category: Cyclic c4 symmetry]] | ||
[[Category: | [[Category: Pbf-2]] | ||
[[Category: | [[Category: Plant]] | ||
[[Category: | [[Category: Single strand dna binding protein]] | ||
[[Category: | [[Category: Transcriptionnal activator]] | ||
[[Category: | [[Category: Whirly]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:29:31 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 20:29, 2 May 2008
Structure of the plant transcriptional regulator PBF-2
Overview
The crystal structure of p24, the single-stranded DNA (ssDNA) binding subunit of the plant defense transcription factor PBF-2, has been determined to 2.3 A resolution. p24 is representative of a novel family of ubiquitous plant-specific proteins that we refer to as the Whirly family because of their quaternary structure. PBF-2 is composed of four p24 molecules that interact through a helix-loop-helix motif. This interaction produces a central pore, with beta-strands radiating outwards, resulting in a whirligig appearance to the quaternary structure. The noncrystallographic C(4) symmetry arrangement of p24 subunits is novel for ssDNA binding proteins and may explain the binding specificity of PBF-2. This structural arrangement also supports the role of PBF-2 in binding melted promoter regions to modulate gene expression.
About this Structure
1L3A is a Single protein structure of sequence from Solanum tuberosum. Full crystallographic information is available from OCA.
Reference
A new family of plant transcription factors displays a novel ssDNA-binding surface., Desveaux D, Allard J, Brisson N, Sygusch J, Nat Struct Biol. 2002 Jul;9(7):512-7. PMID:12080340 Page seeded by OCA on Fri May 2 23:29:31 2008
