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==Solution NMR structure of the chromo domain of the chromobox protein homolog 4==
==Solution NMR structure of the chromo domain of the chromobox protein homolog 4==
<StructureSection load='2k28' size='340' side='right'caption='[[2k28]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2k28' size='340' side='right'caption='[[2k28]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2k28]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K28 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2k28]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K28 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k28 OCA], [https://pdbe.org/2k28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k28 RCSB], [https://www.ebi.ac.uk/pdbsum/2k28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k28 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k28 OCA], [https://pdbe.org/2k28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k28 RCSB], [https://www.ebi.ac.uk/pdbsum/2k28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k28 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CBX4_HUMAN CBX4_HUMAN]] E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression.<ref>PMID:12679040</ref> <ref>PMID:16061479</ref> <ref>PMID:17018294</ref> <ref>PMID:21282530</ref> <ref>PMID:22825850</ref>  Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.<ref>PMID:12679040</ref> <ref>PMID:16061479</ref> <ref>PMID:17018294</ref> <ref>PMID:21282530</ref> <ref>PMID:22825850</ref>
[https://www.uniprot.org/uniprot/CBX4_HUMAN CBX4_HUMAN] E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression.<ref>PMID:12679040</ref> <ref>PMID:16061479</ref> <ref>PMID:17018294</ref> <ref>PMID:21282530</ref> <ref>PMID:22825850</ref>  Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.<ref>PMID:12679040</ref> <ref>PMID:16061479</ref> <ref>PMID:17018294</ref> <ref>PMID:21282530</ref> <ref>PMID:22825850</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Fares, C]]
[[Category: Fares C]]
[[Category: Gutmanas, A]]
[[Category: Gutmanas A]]
[[Category: Kaustov, L]]
[[Category: Kaustov L]]
[[Category: Lemak, A]]
[[Category: Lemak A]]
[[Category: Loppnau, P]]
[[Category: Loppnau P]]
[[Category: Min, J]]
[[Category: Min J]]
[[Category: Quyang, H]]
[[Category: Quyang H]]
[[Category: Ravichandran, M]]
[[Category: Ravichandran M]]
[[Category: Structural genomic]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Alpha/beta protein]]
[[Category: Alternative splicing]]
[[Category: Chromatin regulator]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Repressor]]
[[Category: Sgc]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Ubl conjugation]]
[[Category: Ubl conjugation pathway]]
Retrieved from "https://proteopedia.org/2k28"