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==Solution NMR structure of N-terminal domain of human pirh2. Northeast Structural Genomics Consortium (NESG) target HT2A==
==Solution NMR structure of N-terminal domain of human pirh2. Northeast Structural Genomics Consortium (NESG) target HT2A==
<StructureSection load='2k2c' size='340' side='right'caption='[[2k2c]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='2k2c' size='340' side='right'caption='[[2k2c]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2k2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2C FirstGlance]. <br>
<table><tr><td colspan='2'>[[2k2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2k2d|2k2d]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RCHY1, ARNIP, CHIMP, PIRH2, RNF199, ZNF363 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2c OCA], [https://pdbe.org/2k2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2c RCSB], [https://www.ebi.ac.uk/pdbsum/2k2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2c ProSAT], [https://www.topsan.org/Proteins/NESGC/2k2c TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2c OCA], [https://pdbe.org/2k2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2c RCSB], [https://www.ebi.ac.uk/pdbsum/2k2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2c ProSAT], [https://www.topsan.org/Proteins/NESGC/2k2c TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ZN363_HUMAN ZN363_HUMAN]] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.<ref>PMID:19483087</ref> <ref>PMID:16914734</ref> <ref>PMID:18006823</ref> <ref>PMID:17721809</ref> <ref>PMID:21994467</ref> <ref>PMID:21791603</ref> <ref>PMID:19043414</ref>
[https://www.uniprot.org/uniprot/ZN363_HUMAN ZN363_HUMAN] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.<ref>PMID:19483087</ref> <ref>PMID:16914734</ref> <ref>PMID:18006823</ref> <ref>PMID:17721809</ref> <ref>PMID:21994467</ref> <ref>PMID:21791603</ref> <ref>PMID:19043414</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Karra, M]]
[[Category: Karra M]]
[[Category: Lemak, A]]
[[Category: Lemak A]]
[[Category: Structural genomic]]
[[Category: Sheng Y]]
[[Category: Sheng, Y]]
[[Category: Srisailam S]]
[[Category: Srisailam, S]]
[[Category: Sunnerhagen M]]
[[Category: Sunnerhagen, M]]
[[Category: Wu B]]
[[Category: Wu, B]]
[[Category: Cytoplasm]]
[[Category: Metal binding protein]]
[[Category: Metal-binding]]
[[Category: Nesg]]
[[Category: Nucleus]]
[[Category: PSI, Protein structure initiative]]
[[Category: Zinc-binding protein]]
[[Category: Zinc-finger]]
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