2kg4: Difference between revisions
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==Three-dimensional structure of human Gadd45alpha in solution by NMR== | ==Three-dimensional structure of human Gadd45alpha in solution by NMR== | ||
<StructureSection load='2kg4' size='340' side='right'caption='[[2kg4 | <StructureSection load='2kg4' size='340' side='right'caption='[[2kg4]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2kg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KG4 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg4 OCA], [https://pdbe.org/2kg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg4 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg4 OCA], [https://pdbe.org/2kg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg4 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/GA45A_HUMAN GA45A_HUMAN] In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Blanco | [[Category: Blanco FJ]] | ||
[[Category: Campos-Olivas | [[Category: Campos-Olivas R]] | ||
[[Category: Diercks | [[Category: Diercks T]] | ||
[[Category: Pantoja-Uceda | [[Category: Pantoja-Uceda D]] | ||
[[Category: Prieto | [[Category: Prieto J]] | ||
[[Category: Sanchez | [[Category: Sanchez R]] | ||
