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==Kalirin DH1 NMR structure==
==Kalirin DH1 NMR structure==
<StructureSection load='2kr9' size='340' side='right'caption='[[2kr9]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='2kr9' size='340' side='right'caption='[[2kr9]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KR9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KR9 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nty|1nty]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kr9 OCA], [https://pdbe.org/2kr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kr9 RCSB], [https://www.ebi.ac.uk/pdbsum/2kr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kr9 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kalrn, Duo, Hapip ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kr9 OCA], [https://pdbe.org/2kr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kr9 RCSB], [https://www.ebi.ac.uk/pdbsum/2kr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kr9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/KALRN_RAT KALRN_RAT]] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.<ref>PMID:10692441</ref> <ref>PMID:11606631</ref> <ref>PMID:15950621</ref>
[https://www.uniprot.org/uniprot/KALRN_RAT KALRN_RAT] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.<ref>PMID:10692441</ref> <ref>PMID:11606631</ref> <ref>PMID:15950621</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Rattus norvegicus]]
[[Category: Gorbatyuk, V Y]]
[[Category: Gorbatyuk VY]]
[[Category: Hoch, J C]]
[[Category: Hoch JC]]
[[Category: Schiller, M R]]
[[Category: Schiller MR]]
[[Category: Cytoskeleton]]
[[Category: Dbl-family gef]]
[[Category: Disulfide bond]]
[[Category: Guanine-nucleotide releasing factor]]
[[Category: Immunoglobulin domain]]
[[Category: Kinase]]
[[Category: Rho gtpase gef]]
[[Category: Transferase]]
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