2kz5: Difference between revisions
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==Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B== | ==Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B== | ||
<StructureSection load='2kz5' size='340' side='right'caption='[[2kz5 | <StructureSection load='2kz5' size='340' side='right'caption='[[2kz5]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2kz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZ5 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [https://pdbe.org/2kz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2kz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz5 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz5 OCA], [https://pdbe.org/2kz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2kz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kz5 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/NFE2_HUMAN NFE2_HUMAN] Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.<ref>PMID:11154691</ref> <ref>PMID:16287851</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Acton | [[Category: Acton TB]] | ||
[[Category: Ciccosanti | [[Category: Ciccosanti C]] | ||
[[Category: Everett | [[Category: Everett JK]] | ||
[[Category: Janjua | [[Category: Janjua H]] | ||
[[Category: Liu | [[Category: Liu G]] | ||
[[Category: Montelione | [[Category: Montelione GT]] | ||
[[Category: Shastry R]] | |||
[[Category: Shastry | [[Category: Tong S]] | ||
[[Category: Tong | [[Category: Xiao R]] | ||
[[Category: Xiao | |||
