2l76: Difference between revisions
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==Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto== | ==Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto== | ||
<StructureSection load='2l76' size='340' side='right'caption='[[2l76 | <StructureSection load='2l76' size='340' side='right'caption='[[2l76]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2l76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2l76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L76 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l76 OCA], [https://pdbe.org/2l76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l76 RCSB], [https://www.ebi.ac.uk/pdbsum/2l76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l76 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l76 OCA], [https://pdbe.org/2l76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l76 RCSB], [https://www.ebi.ac.uk/pdbsum/2l76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l76 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Dhe-Paganon | [[Category: Dhe-Paganon S]] | ||
[[Category: Doherty | [[Category: Doherty R]] | ||
[[Category: Houliston | [[Category: Houliston S]] | ||
[[Category: Semesi A]] | |||
[[Category: Wu B]] | |||
[[Category: Semesi | [[Category: Yee A]] | ||
[[Category: Wu | |||
[[Category: Yee | |||
Revision as of 08:52, 14 June 2023
Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto
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