2m3i: Difference between revisions
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==Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors== | ==Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors== | ||
<StructureSection load='2m3i' size='340' side='right'caption='[[2m3i | <StructureSection load='2m3i' size='340' side='right'caption='[[2m3i]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2m3i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M3I FirstGlance]. <br> | <table><tr><td colspan='2'>[[2m3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_lividus Conus lividus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M3I FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3i OCA], [https://pdbe.org/2m3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m3i RCSB], [https://www.ebi.ac.uk/pdbsum/2m3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m3i ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3i OCA], [https://pdbe.org/2m3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m3i RCSB], [https://www.ebi.ac.uk/pdbsum/2m3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m3i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CA1C_CONLI CA1C_CONLI] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits alpha-3-beta-4, alpha-6/alpha-3-beta-4, and alpha-2-beta-4 nAChRs.[UniProtKB:K8DWB5] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Conus lividus]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Akcan | [[Category: Akcan M]] | ||
[[Category: Christensen | [[Category: Christensen S]] | ||
[[Category: Craik | [[Category: Craik DJ]] | ||
[[Category: Hu | [[Category: Hu Y]] | ||
[[Category: Luo | [[Category: Luo S]] | ||
[[Category: McIntosh | [[Category: McIntosh JM]] | ||
[[Category: Wu | [[Category: Wu Y]] | ||
[[Category: Zhangsun | [[Category: Zhangsun D]] | ||
[[Category: Zhu | [[Category: Zhu X]] | ||
Revision as of 09:27, 14 June 2023
Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors
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