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==Interplay between phosphatidyl-inositol-phosphates and claudins upon binding to the 1st PDZ domain of zonula occludens 1==
==Interplay between phosphatidyl-inositol-phosphates and claudins upon binding to the 1st PDZ domain of zonula occludens 1==
<StructureSection load='2rrm' size='340' side='right'caption='[[2rrm]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2rrm' size='340' side='right'caption='[[2rrm]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rrm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRM FirstGlance]. <br>
<table><tr><td colspan='2'>[[2rrm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRM FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rrm OCA], [https://pdbe.org/2rrm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rrm RCSB], [https://www.ebi.ac.uk/pdbsum/2rrm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rrm ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rrm OCA], [https://pdbe.org/2rrm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rrm RCSB], [https://www.ebi.ac.uk/pdbsum/2rrm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rrm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ZO1_MOUSE ZO1_MOUSE]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (By similarity).  
[https://www.uniprot.org/uniprot/ZO1_MOUSE ZO1_MOUSE] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Furuse, M]]
[[Category: Furuse M]]
[[Category: Goda, N]]
[[Category: Goda N]]
[[Category: Hiroaki, H]]
[[Category: Hiroaki H]]
[[Category: Ikegami, T]]
[[Category: Ikegami T]]
[[Category: Satomura, K]]
[[Category: Satomura K]]
[[Category: Taniguchi, R]]
[[Category: Taniguchi R]]
[[Category: Umetsu, Y]]
[[Category: Umetsu Y]]
[[Category: Cell adhesion]]
[[Category: Intercellular adhesion]]
[[Category: Pdz domain]]
[[Category: Protein protein interaction]]
[[Category: Tight junction protein 1]]
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