5giw: Difference between revisions

<StructureSection load='5giw' size='340' side='right'caption='[[5giw]]' scene=''>

<table><tr><td colspan='2'>[[5giw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GIW FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DSN:D-SERINE'>DSN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5giw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5giw OCA], [https://pdbe.org/5giw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5giw RCSB], [https://www.ebi.ac.uk/pdbsum/5giw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5giw ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/HUNIN_HUMAN HUNIN_HUMAN] Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.<ref>PMID:11371646</ref> <ref>PMID:14561895</ref> <ref>PMID:11717357</ref> <ref>PMID:12732850</ref> <ref>PMID:15153530</ref>  

[[Category: Alsanousi N]]

[[Category: Fujiwara T]]

[[Category: Furuita K]]

[[Category: Kojima C]]

[[Category: Sugiki T]]