5lg7: Difference between revisions
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==Solution NMR structure of Tryptophan to Arginine mutant of Arkadia RING domain== | ==Solution NMR structure of Tryptophan to Arginine mutant of Arkadia RING domain== | ||
<StructureSection load='5lg7' size='340' side='right'caption='[[5lg7 | <StructureSection load='5lg7' size='340' side='right'caption='[[5lg7]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5lg7]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5lg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LG7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lg7 OCA], [https://pdbe.org/5lg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lg7 RCSB], [https://www.ebi.ac.uk/pdbsum/5lg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lg7 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/RN111_HUMAN RN111_HUMAN] Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme.<ref>PMID:14657019</ref> <ref>PMID:16601693</ref> <ref>PMID:17591695</ref> <ref>PMID:22411132</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bentrop | [[Category: Bentrop D]] | ||
[[Category: Birkou | [[Category: Birkou M]] | ||
[[Category: Chasapis | [[Category: Chasapis CT]] | ||
[[Category: Episkopou | [[Category: Episkopou V]] | ||
[[Category: Herrmann | [[Category: Herrmann T]] | ||
[[Category: Lelli | [[Category: Lelli M]] | ||
[[Category: Loutsidou | [[Category: Loutsidou AK]] | ||
[[Category: Spyroulias | [[Category: Spyroulias GA]] | ||
