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==Solution NMR structures of two alternative conformations of E. coli tryptophan repressor in dynamic equilibrium==
==Solution NMR structures of two alternative conformations of E. coli tryptophan repressor in dynamic equilibrium==
<StructureSection load='5tm0' size='340' side='right'caption='[[5tm0]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='5tm0' size='340' side='right'caption='[[5tm0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5tm0]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TM0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TM0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5tm0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TM0 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tm0 OCA], [http://pdbe.org/5tm0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tm0 RCSB], [http://www.ebi.ac.uk/pdbsum/5tm0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tm0 ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tm0 OCA], [https://pdbe.org/5tm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tm0 RCSB], [https://www.ebi.ac.uk/pdbsum/5tm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tm0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TRPR_ECO57 TRPR_ECO57]] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).  
[https://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Escherichia coli O157:H7]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Carey, J]]
[[Category: Carey J]]
[[Category: Harish, B]]
[[Category: Harish B]]
[[Category: Kornhaber, G J]]
[[Category: Kornhaber GJ]]
[[Category: Montelione, G T]]
[[Category: Montelione GT]]
[[Category: Structural genomic]]
[[Category: Swapna GVT]]
[[Category: Swapna, G V.T]]
[[Category: Nesg]]
[[Category: Psi-biology]]
[[Category: Transcription]]
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