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==NMR structure of the SARS Coronavirus E protein pentameric ion channel==
==NMR structure of the SARS Coronavirus E protein pentameric ion channel==
<StructureSection load='5x29' size='340' side='right' caption='[[5x29]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
<StructureSection load='5x29' size='340' side='right'caption='[[5x29]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5x29]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X29 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5x29]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X29 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mm4|2mm4]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x29 OCA], [https://pdbe.org/5x29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x29 RCSB], [https://www.ebi.ac.uk/pdbsum/5x29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x29 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E, sM, 4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x29 OCA], [http://pdbe.org/5x29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x29 RCSB], [http://www.ebi.ac.uk/pdbsum/5x29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x29 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VEMP_CVHSA VEMP_CVHSA]] Component of the viral envelope that plays a central role in virus morphogenesis and assembly. It is sufficient to form virus-like particles. Seems to be important for creating the membrane curvature needed to acquire the rounded, stable and infectious particle phenotype. Acts as a viroporin, inducing the formation of hydrophilic pores in cellular membranes. Also induces apoptosis (By similarity).  
[https://www.uniprot.org/uniprot/VEMP_SARS VEMP_SARS] Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.[HAMAP-Rule:MF_04204]<ref>PMID:24788150</ref> <ref>PMID:26331680</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cvhsa]]
[[Category: Large Structures]]
[[Category: Li, Y]]
[[Category: Severe acute respiratory syndrome-related coronavirus]]
[[Category: Surya, W]]
[[Category: Li Y]]
[[Category: Torres, J]]
[[Category: Surya W]]
[[Category: Envelope protein]]
[[Category: Torres J]]
[[Category: Ion channel]]
[[Category: Membrane protein]]
[[Category: Pentamer]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/5x29"