5y95: Difference between revisions

<StructureSection load='5y95' size='340' side='right'caption='[[5y95]]' scene=''>

<table><tr><td colspan='2'>[[5y95]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y95 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8TL:propan-2-yl+(3R,6S,9aS)-3-ethyl-8-(3-methylbutyl)-6-(2-methylsulfanylethyl)-4,7-bis(oxidanylidene)-9,9a-dihydro-6H-pyrazino[2,1-c][1,2,4]oxadiazine-1-carboxylate'>8TL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y95 OCA], [https://pdbe.org/5y95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y95 RCSB], [https://www.ebi.ac.uk/pdbsum/5y95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y95 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref>  

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Hirao Y]]

[[Category: Kurita J]]

[[Category: Nishimura Y]]