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==Solution structure of mice Met-CCL5/RANTES==
==Solution structure of mice Met-CCL5/RANTES==
<StructureSection load='5yam' size='340' side='right'caption='[[5yam]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='5yam' size='340' side='right'caption='[[5yam]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5yam]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YAM FirstGlance]. <br>
<table><tr><td colspan='2'>[[5yam]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YAM FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cmd|5cmd]], [[1eqt|1eqt]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yam OCA], [https://pdbe.org/5yam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yam RCSB], [https://www.ebi.ac.uk/pdbsum/5yam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yam ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ccl5, Scya5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yam OCA], [http://pdbe.org/5yam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yam RCSB], [http://www.ebi.ac.uk/pdbsum/5yam PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yam ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CCL5_MOUSE CCL5_MOUSE]] Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.[UniProtKB:P13501]  
[https://www.uniprot.org/uniprot/CCL5_MOUSE CCL5_MOUSE] Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.[UniProtKB:P13501]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Chen, S P]]
[[Category: Chen S-P]]
[[Category: Chen, Y C]]
[[Category: Chen Y-C]]
[[Category: Lee, Y Z]]
[[Category: Lee Y-Z]]
[[Category: Sue, S C]]
[[Category: Sue S-C]]
[[Category: Antagonist]]
[[Category: Chemokine]]
[[Category: Cytokine]]
[[Category: Dimer]]
[[Category: Heparin]]
[[Category: Inflammatory]]
Retrieved from "https://proteopedia.org/5yam"