6ax2: Difference between revisions
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==Solution structure of Magi3 a specific insect toxin from the spider Macrothele gigas== | ==Solution structure of Magi3 a specific insect toxin from the spider Macrothele gigas== | ||
<StructureSection load='6ax2' size='340' side='right'caption='[[6ax2 | <StructureSection load='6ax2' size='340' side='right'caption='[[6ax2]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6ax2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6ax2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrothele_gigas Macrothele gigas]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AX2 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ax2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ax2 OCA], [https://pdbe.org/6ax2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ax2 RCSB], [https://www.ebi.ac.uk/pdbsum/6ax2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ax2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TX22A_MACGS TX22A_MACGS] Competes for binding at site 3 of the insect voltage-gated sodium channel (Nav) (PubMed:12860384). Insecticidal neurotoxin (PubMed:12860384, PubMed:29247580). Causes temporary paralysis to lepidopteran larvae (10.3 nmol/g) or to crickets (doses from 0.93 to 119 ug/g) (PubMed:12860384, PubMed:29247580). Is not toxic to mice when injected intracranially (high doses) (PubMed:12860384, PubMed:29247580).<ref>PMID:12860384</ref> <ref>PMID:29247580</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Macrothele gigas]] | ||
[[Category: Escobedo-Gonzalez | [[Category: Escobedo-Gonzalez FC]] | ||
[[Category: Titaux-Delgado GA]] | |||
[[Category: Titaux-Delgado | [[Category: Del Rio-Portilla F]] | ||
[[Category: | |||
Revision as of 10:37, 14 June 2023
Solution structure of Magi3 a specific insect toxin from the spider Macrothele gigas
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