6bi6

Solution NMR structure of uncharacterized protein YejG

spinqualitylabelsall models 6bi6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6bi6 is a 1 chain structure with sequence from Escherichia coli K-12. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function YEJG_ECOLI Publication Abstract from PubMed InterPro family IPR020489 comprises ~1000 uncharacterized bacterial proteins. Previously we showed that overexpressing the Escherichia coli representative of this family, EcYejG, conferred low-level resistance to aminoglycoside antibiotics. In an attempt to shed light on the biochemical function of EcYejG, we have solved its structure using multinuclear solution NMR spectroscopy. The structure most closely resembles that of domain III from elongation factor G (EF-G). EF-G catalyzes ribosomal translocation and mutations in EF-G have also been associated with aminoglycoside resistance. While we were unable to demonstrate a direct interaction between EcYejG and the ribosome, the protein might play a role in translation. The uncharacterized bacterial protein YejG has the same architecture as domain III of elongation factor G.,Mohanty B, Hanson-Manful P, Finn TJ, Chambers CR, McKellar JLO, Macindoe I, Helder S, Setiyaputra S, Zhong Y, Mackay JP, Patrick WM Proteins. 2019 Apr 8. doi: 10.1002/prot.25687. PMID:30958578 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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