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==Solution structure of double knot toxin (DkTx)==
==Solution structure of double knot toxin (DkTx)==
<StructureSection load='6cuc' size='340' side='right'caption='[[6cuc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='6cuc' size='340' side='right'caption='[[6cuc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6cuc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CUC FirstGlance]. <br>
<table><tr><td colspan='2'>[[6cuc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyriopagopus_schmidti Cyriopagopus schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CUC FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cuc OCA], [http://pdbe.org/6cuc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cuc RCSB], [http://www.ebi.ac.uk/pdbsum/6cuc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cuc ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cuc OCA], [https://pdbe.org/6cuc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cuc RCSB], [https://www.ebi.ac.uk/pdbsum/6cuc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cuc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DKTX_CYRSC DKTX_CYRSC] Selectively activates the heat-activated TRPV1 channel. It binds to TRPV1 in an open state-dependent manner, trapping it there to produce irreversible currents (PubMed:20510930, PubMed:26880553, PubMed:27281200). It binds to the outer edge of the external pore of TRPV1 in a counterclockwise configuration, using a limited protein-protein interface and inserting hydrophobic residues into the bilayer (PubMed:26880553, PubMed:27281200). It also partitions naturally into membranes, with the two lobes exhibiting opposing energetics for membrane partitioning (K1) and channel activation (K2) (PubMed:26880553). In addition, the toxin disrupts a cluster of hydrophobic residues behind the selectivity filter that are critical for channel activation (PubMed:26880553).<ref>PMID:20510930</ref> <ref>PMID:26880553</ref> <ref>PMID:27281200</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cyriopagopus schmidti]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mobli, M]]
[[Category: Mobli M]]
[[Category: Ramanujam, V]]
[[Category: Ramanujam V]]
[[Category: Dktx]]
[[Category: Ick]]
[[Category: Spider toxin]]
[[Category: Tarantula]]
[[Category: Toxin]]
[[Category: Trpv1]]
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