6mk5: Difference between revisions

<StructureSection load='6mk5' size='340' side='right'caption='[[6mk5]]' scene=''>

<table><tr><td colspan='2'>[[6mk5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Grammostola_porteri Grammostola porteri]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MK5 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mk5 OCA], [https://pdbe.org/6mk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mk5 RCSB], [https://www.ebi.ac.uk/pdbsum/6mk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mk5 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TX15_GRAPO TX15_GRAPO] Potent voltage-gated sodium channel blocker (PubMed:25658507). Potently inhibits the voltage-gated sodium channels Nav1.7/SCN9A (IC(50)=0.58-10 nM) (PubMed:25658507, PubMed:26999206) (By similarity). Shows a moderate activity on Nav1.1/SCN1A (IC(50)=6 nM), Nav1.2/SCN2A (IC(50)=5 nM), Nav1.3/SCN3A (IC(50)=20.3-170 nM), Nav1.4/SCN4A (IC(50)=200-326 nM), and Nav1.6/SCN8A (IC(50)=17 nM) (PubMed:25658507, PubMed:26999206) (By similarity). Shows an unclear inhibition of Nav1.5/SCN5A (IC(50)=140 nM to >10 uM) and Nav1.8/SCN10A (IC(50)=68-12200 nM) (PubMed:25658507, PubMed:26999206) (By similarity). Weakly blocks the low voltage-gated calcium channels Cav3.1/CACNA1G (30% inhibition of the peak current by 9.8 nM of the toxin) (By similarity).[UniProtKB:P0DJA9][UniProtKB:P0DL73]<ref>PMID:25658507</ref>  

[[Category: Schroeder CI]]