6n68: Difference between revisions
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==NMR solution structure of Protonectin (Agelaia pallipes pallipes) interacting with SDS micelles: an antimicrobial peptide with anticancer activity on breast cancer cells== | ==NMR solution structure of Protonectin (Agelaia pallipes pallipes) interacting with SDS micelles: an antimicrobial peptide with anticancer activity on breast cancer cells== | ||
<StructureSection load='6n68' size='340' side='right'caption='[[6n68 | <StructureSection load='6n68' size='340' side='right'caption='[[6n68]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6n68]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N68 FirstGlance]. <br> | <table><tr><td colspan='2'>[[6n68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agelaia_pallipes Agelaia pallipes]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N68 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n68 OCA], [https://pdbe.org/6n68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n68 RCSB], [https://www.ebi.ac.uk/pdbsum/6n68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n68 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n68 OCA], [https://pdbe.org/6n68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n68 RCSB], [https://www.ebi.ac.uk/pdbsum/6n68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n68 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PROTO_AGEPP PROTO_AGEPP] Shows potent antimicrobial action against both Gram-positive and Gram-negative bacteria (MIC=25 ug/ml or 32-63 uM against E.coli, MIC=1.7 ug/ml against P.aeruginosa, MIC=3.1 ug/ml or 4 uM against B.subtilis, MIC=8 uM against S.epidermis, and MIC=12.5 ug/ml or 8 uM against S.aureus) (PubMed:15225564, PubMed:23836163). Acts by disrupting the integrity of the outer and inner bacterial membranes (Probable). Adopts an amphipathic alpha helical conformation in membrane that is essential for the membrane disrupting activity (PubMed:23836163). Mast cell degranulator that induces a potent chemotaxis in polymorphonucleated leukocyte (PMNL) cells (PubMed:15052574, PubMed:15225564). Shows no or weak hemolytic activity (PubMed:15052574, PubMed:15225564).<ref>PMID:15052574</ref> <ref>PMID:15225564</ref> <ref>PMID:23836163</ref> <ref>PMID:23836163</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Agelaia pallipes]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Dos Santos Cabrera MP]] | ||
[[Category: Fadel | [[Category: Fadel V]] | ||
[[Category: Martins | [[Category: Martins DB]] | ||
