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==Solution structure of the fourth WW domain of WWP2 with GB1-tag==
==Solution structure of the fourth WW domain of WWP2 with GB1-tag==
<StructureSection load='6rss' size='340' side='right'caption='[[6rss]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='6rss' size='340' side='right'caption='[[6rss]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6rss]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RSS FirstGlance]. <br>
<table><tr><td colspan='2'>[[6rss]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RSS FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.26 2.3.2.26] </span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rss OCA], [https://pdbe.org/6rss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rss RCSB], [https://www.ebi.ac.uk/pdbsum/6rss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rss ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rss OCA], [http://pdbe.org/6rss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rss RCSB], [http://www.ebi.ac.uk/pdbsum/6rss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rss ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/WWP2_HUMAN WWP2_HUMAN]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.<ref>PMID:19274063</ref> <ref>PMID:19651900</ref>
[https://www.uniprot.org/uniprot/WWP2_HUMAN WWP2_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.<ref>PMID:19274063</ref> <ref>PMID:19651900</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6rss" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6rss" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Transferase]]
[[Category: Blumenschein TMA]]
[[Category: Blumenschein, T M.A]]
[[Category: Chantry A]]
[[Category: Chantry, A]]
[[Category: Tolchard J]]
[[Category: Tolchard, J]]
[[Category: Wahl LC]]
[[Category: Wahl, L C]]
[[Category: Watt JE]]
[[Category: Watt, J E]]
[[Category: E3 ubiquitin ligase]]
[[Category: Nedd4]]
[[Category: Ppxy motif binding]]
[[Category: Protein binding]]
[[Category: Three-stranded antiparallel beta-sheet]]
Retrieved from "https://proteopedia.org/6rss"