6t33

The unusual structure of Ruminococcin C1 antimicrobial peptide confers activity against clinical pathogens

spinqualitylabelsall models 6t33 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6t33 is a 1 chain structure with sequence from Ruminococcus gnavus E1. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function F8QV07_RUMGN Publication Abstract from PubMed The emergence of superbugs developing resistance to antibiotics and the resurgence of microbial infections have led scientists to start an antimicrobial arms race. In this context, we have previously identified an active RiPP, the Ruminococcin C1, naturally produced by Ruminococcus gnavus E1, a symbiont of the healthy human intestinal microbiota. This RiPP, subclassified as a sactipeptide, requires the host digestive system to become active against pathogenic Clostridia and multidrug-resistant strains. Here we report its unique compact structure on the basis of four intramolecular thioether bridges with reversed stereochemistry introduced posttranslationally by a specific radical-SAM sactisynthase. This structure confers to the Ruminococcin C1 important clinical properties including stability to digestive conditions and physicochemical treatments, a higher affinity for bacteria than simulated intestinal epithelium, a valuable activity at therapeutic doses on a range of clinical pathogens, mediated by energy resources disruption, and finally safety for human gut tissues. The unusual structure of Ruminococcin C1 antimicrobial peptide confers clinical properties.,Roblin C, Chiumento S, Bornet O, Nouailler M, Muller CS, Jeannot K, Basset C, Kieffer-Jaquinod S, Coute Y, Torelli S, Le Pape L, Schunemann V, Olleik H, De La Villeon B, Sockeel P, Di Pasquale E, Nicoletti C, Vidal N, Poljak L, Iranzo O, Giardina T, Fons M, Devillard E, Polard P, Maresca M, Perrier J, Atta M, Guerlesquin F, Lafond M, Duarte V Proc Natl Acad Sci U S A. 2020 Jul 27. pii: 2004045117. doi:, 10.1073/pnas.2004045117. PMID:32719135 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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