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==Solution structure of U1-A RRM2 (190-282)==
==Solution structure of U1-A RRM2 (190-282)==
<StructureSection load='7aep' size='340' side='right'caption='[[7aep]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='7aep' size='340' side='right'caption='[[7aep]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7aep]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AEP FirstGlance]. <br>
<table><tr><td colspan='2'>[[7aep]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AEP FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2u1a|2u1a]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aep OCA], [https://pdbe.org/7aep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aep RCSB], [https://www.ebi.ac.uk/pdbsum/7aep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aep ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SNRPA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aep OCA], [https://pdbe.org/7aep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aep RCSB], [https://www.ebi.ac.uk/pdbsum/7aep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aep ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Allain, F H]]
[[Category: Allain FH]]
[[Category: Campagne, S]]
[[Category: Campagne S]]
[[Category: Rrm]]
[[Category: Splicing]]
[[Category: U1 snrnp tail]]
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