7do1: Difference between revisions
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==== | ==Solution structure of a heteromolecular telomeric (3+1) G-quadruplex containing right loop progression== | ||
<StructureSection load='7do1' size='340' side='right'caption='[[7do1]]' scene=''> | <StructureSection load='7do1' size='340' side='right'caption='[[7do1]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full | <table><tr><td colspan='2'>[[7do1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DO1 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7do1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7do1 OCA], [https://pdbe.org/7do1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7do1 RCSB], [https://www.ebi.ac.uk/pdbsum/7do1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7do1 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7do1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7do1 OCA], [https://pdbe.org/7do1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7do1 RCSB], [https://www.ebi.ac.uk/pdbsum/7do1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7do1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The final 3'-terminal residue of the telomeric DNA G-overhang is inherently less precise. Here, we describe how alteration of the last 3'-terminal base affects the mutual recognition between two different G-rich oligomers of human telomeric DNA in the formation of heteromolecular G-quadruplexes (hetero-GQs). Associations between three- and single-repeat fragments of human telomeric DNA, target d(GGGTTAGGGTTAGGG) and probe d(TAGGGT), in Na+ solution yield two coexisting forms of (3 + 1) hybrid hetero-GQs: the kinetically favourable LLP-form (left loop progression) and the thermodynamically controlled RLP-form (right loop progression). However, only the adoption of a single LLP-form has been previously reported between the same probe d(TAGGGT) and a target variant d(GGGTTAGGGTTAGGGT) having one extra 3'-end thymine. Moreover, the flanking base alterations of short G-rich probe variants also significantly affect the loop progressions of hetero-GQs. Although seemingly two pseudo-mirror counter partners, the RLP-form exhibits a preference over the LLP-form to be recognized by a low equivalent of fluorescence dye thioflavin T (ThT). To a greater extent, ThT preferentially binds to RLP hetero-GQ than with the corresponding telomeric DNA duplex context or several other representative unimolecular GQs. | |||
Two coexisting pseudo-mirror heteromolecular telomeric G-quadruplexes in opposite loop progressions differentially recognized by a low equivalent of Thioflavin T.,Fu W, Jing H, Xu X, Xu S, Wang T, Hu W, Li H, Zhang N Nucleic Acids Res. 2021 Oct 11;49(18):10717-10734. doi: 10.1093/nar/gkab755. PMID:34500466<ref>PMID:34500466</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7do1" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Fu WQ]] | ||
[[Category: Jing HT]] | |||
[[Category: Zhang N]] | |||
Latest revision as of 11:12, 14 June 2023
Solution structure of a heteromolecular telomeric (3+1) G-quadruplex containing right loop progression
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