7jmy: Difference between revisions
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==Solution NMR structure of human Brd3 ET domain== | ==Solution NMR structure of human Brd3 ET domain== | ||
<StructureSection load='7jmy' size='340' side='right'caption='[[7jmy | <StructureSection load='7jmy' size='340' side='right'caption='[[7jmy]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7jmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[7jmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JMY FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jmy OCA], [https://pdbe.org/7jmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jmy RCSB], [https://www.ebi.ac.uk/pdbsum/7jmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jmy ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jmy OCA], [https://pdbe.org/7jmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jmy RCSB], [https://www.ebi.ac.uk/pdbsum/7jmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jmy ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 7jmy" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7jmy" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aiyer | [[Category: Aiyer S]] | ||
[[Category: Montelione | [[Category: Montelione GT]] | ||
[[Category: Roth | [[Category: Roth JM]] | ||
[[Category: Swapna | [[Category: Swapna GVT]] | ||
Latest revision as of 11:13, 14 June 2023
Solution NMR structure of human Brd3 ET domain
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