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==Structure and topology of DWORF in bicelles by oriented solid-state NMR==
==Structure and topology of DWORF in bicelles by oriented solid-state NMR==
<StructureSection load='7mpa' size='340' side='right'caption='[[7mpa]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='7mpa' size='340' side='right'caption='[[7mpa]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7mpa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MPA FirstGlance]. <br>
<table><tr><td colspan='2'>[[7mpa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MPA FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STRIT1, DWORF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mpa OCA], [https://pdbe.org/7mpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mpa RCSB], [https://www.ebi.ac.uk/pdbsum/7mpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mpa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mpa OCA], [https://pdbe.org/7mpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mpa RCSB], [https://www.ebi.ac.uk/pdbsum/7mpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mpa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DWORF_HUMAN DWORF_HUMAN]] Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).[UniProtKB:P0DN83]  
[https://www.uniprot.org/uniprot/DWORF_HUMAN DWORF_HUMAN] Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).[UniProtKB:P0DN83]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Reddy, U V]]
[[Category: Reddy UV]]
[[Category: Veglia, G V]]
[[Category: Veglia GV]]
[[Category: Weber, D K]]
[[Category: Weber DK]]
[[Category: Chemical shift anisotropy]]
[[Category: Dipolar coupling]]
[[Category: Membrane protein]]
[[Category: Miniprotein]]
[[Category: Oriented solid state nmr spectroscopy]]
[[Category: Regulin]]
[[Category: Sarcoplasmic reticulum]]
[[Category: Separated local field]]
Retrieved from "https://proteopedia.org/7mpa"