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==Crystal Structure of Serine protease Hepsin in complex with Inhibitor==
==Crystal Structure of Serine protease Hepsin in complex with Inhibitor==
<StructureSection load='5ce1' size='340' side='right' caption='[[5ce1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='5ce1' size='340' side='right'caption='[[5ce1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ce1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CE1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ce1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CE1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=50K:2-[6-(1-HYDROXYCYCLOHEXYL)PYRIDIN-2-YL]-1H-INDOLE-5-CARBOXIMIDAMIDE'>50K</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=50K:2-[6-(1-HYDROXYCYCLOHEXYL)PYRIDIN-2-YL]-1H-INDOLE-5-CARBOXIMIDAMIDE'>50K</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HPN, TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ce1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ce1 OCA], [https://pdbe.org/5ce1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ce1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ce1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ce1 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hepsin Hepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.106 3.4.21.106] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ce1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ce1 OCA], [http://pdbe.org/5ce1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ce1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ce1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ce1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN]] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>
[https://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hepsin]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Anirudha, L]]
[[Category: Anirudha L]]
[[Category: Anita, R C]]
[[Category: Anita RC]]
[[Category: Rao, K N]]
[[Category: Rao KN]]
[[Category: Sangeetha, R]]
[[Category: Sangeetha R]]
[[Category: Subramnay, H]]
[[Category: Subramnay H]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Prostate cancer]]
[[Category: Serine protease]]
Retrieved from "https://proteopedia.org/5ce1"