5cg9: Difference between revisions

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<StructureSection load='5cg9' size='340' side='right'caption='[[5cg9]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
<StructureSection load='5cg9' size='340' side='right'caption='[[5cg9]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5cg9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Amoeba Amoeba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CG9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5cg9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Naegleria_gruberi Naegleria gruberi] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CG9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cg9 OCA], [https://pdbe.org/5cg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cg9 RCSB], [https://www.ebi.ac.uk/pdbsum/5cg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cg9 ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cg8|5cg8]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NAEGRDRAFT_55029 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5762 Amoeba])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cg9 OCA], [http://pdbe.org/5cg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cg9 RCSB], [http://www.ebi.ac.uk/pdbsum/5cg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cg9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TET1_NAEGR TET1_NAEGR] Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), and thereby plays a role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC).<ref>PMID:24390346</ref> <ref>PMID:26323320</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Amoeba]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cheng, X]]
[[Category: Naegleria gruberi]]
[[Category: Dai, N]]
[[Category: Synthetic construct]]
[[Category: Hashimoto, H]]
[[Category: Cheng X]]
[[Category: Pais, J E]]
[[Category: Dai N]]
[[Category: Zhang, X]]
[[Category: Hashimoto H]]
[[Category: Zheng, Y]]
[[Category: Pais JE]]
[[Category: 5-methylcytosine]]
[[Category: Zhang X]]
[[Category: Dioxygenase]]
[[Category: Zheng Y]]
[[Category: Ngtet1]]
[[Category: Oxidoreductase-dna complex]]
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