5cp8: Difference between revisions

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==The effect of isoleucine to alanine mutation on InhA enzyme crystallization pattern and substrate binding loop conformation and flexibility==
==The effect of isoleucine to alanine mutation on InhA enzyme crystallization pattern and substrate binding loop conformation and flexibility==
<StructureSection load='5cp8' size='340' side='right' caption='[[5cp8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5cp8' size='340' side='right'caption='[[5cp8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5cp8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CP8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5cp8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CP8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ETE:2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>ETE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCU:5-HEXYL-2-(2-METHYLPHENOXY)PHENOL'>TCU</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ETE:2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>ETE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCU:5-HEXYL-2-(2-METHYLPHENOXY)PHENOL'>TCU</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5coq|5coq]], [[5cpf|5cpf]], [[5cpb|5cpb]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp8 OCA], [https://pdbe.org/5cp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cp8 RCSB], [https://www.ebi.ac.uk/pdbsum/5cp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp8 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cp8 OCA], [http://pdbe.org/5cp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cp8 RCSB], [http://www.ebi.ac.uk/pdbsum/5cp8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cp8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5cp8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5cp8" style="background-color:#fffaf0;"></div>
==See Also==
*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bommineni, G R]]
[[Category: Large Structures]]
[[Category: Garcia-Diaz, M]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Lai, C T]]
[[Category: Bommineni GR]]
[[Category: Li, H J]]
[[Category: Garcia-Diaz M]]
[[Category: Liu, N]]
[[Category: Lai C-T]]
[[Category: Perrone, V]]
[[Category: Li H-J]]
[[Category: Shah, S]]
[[Category: Liu N]]
[[Category: Simmerling, C]]
[[Category: Perrone V]]
[[Category: Tonge, P J]]
[[Category: Shah S]]
[[Category: Yu, W]]
[[Category: Simmerling C]]
[[Category: Crystal packing fatty acid biosynthesis slow-onset inhibition free energy calculation]]
[[Category: Tonge PJ]]
[[Category: Oxidoreductase]]
[[Category: Yu W]]
Retrieved from "https://proteopedia.org/5cp8"