5cuw: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[5cuw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strco Strco~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUW OCA]. For a guided tour on the structure components use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5CUW FirstGlance].

<table><tr><td colspan='2'>[[5cuw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUW OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5CUW FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

~~<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">SCO3850 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=100226 STRCO])~~</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5cuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cuw OCA], [https://pdbe.org/5cuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cuw RCSB], [https://www.ebi.ac.uk/pdbsum/5cuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cuw ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5cuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cuw OCA], [~~http~~://pdbe.org/5cuw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5cuw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5cuw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5cuw ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/SRTE1_STRCO SRTE1_STRCO] Transpeptidase that anchors surface proteins to the cell wall. Recognizes both Leu-Ala-x-Thr-Gly and Leu-Pro-x-Thr-Gly, with a preference for the former. Unlike the S.aureus sortase it cleaves not only the Thr-Gly motif but also the Ala-X bond; Ala-Glu and Ala-His bonds are better substrates than the Thr-Gly motif in vitro (PubMed:22296345, PubMed:27936128). Among its possible substrates are the chaplins ChpA, ChpB and ChpC; this enzyme is less important for ChpC attachment than is SrtE2. A double knockout mutant of srtE1 and srtE2 shows a developmental defect in aerial hyphae formation more dramatic than that due to chaplin deletion (PubMed:22296345).<ref>PMID:22296345</ref> <ref>PMID:27936128</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

~~[[Category: Strco]]~~

[[Category: Cascio D]]

[[Category: Cascio, D]]

[[Category: Clubb RT]]

[[Category: Clubb~~, R T~~]]

[[Category: Kattke MD]]

[[Category: Kattke~~, M D~~]]

[[Category: Sawaya MR]]

[[Category: Sawaya~~, M R]]~~

~~[[Category: Aminoacyltransferase]]~~

~~[[Category: Bacterial protein]]~~

~~[[Category: Beta barrel]]~~

~~[[Category: Catalytic domain]]~~

~~[[Category: Class e]]~~

~~[[Category: Cysteine endopeptidase]]~~

~~[[Category: Membrane protein]]~~

~~[[Category: Protein binding]]~~

~~[[Category: Sortase]]~~

~~[[Category: Srte]]~~

~~[[Category: Transpeptidase~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='5cuw' size='340' side='right'caption='[[5cuw]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5cuw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CUW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5cuw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CUW FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCO3850 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=100226 STRCO])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cuw OCA], [https://pdbe.org/5cuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cuw RCSB], [https://www.ebi.ac.uk/pdbsum/5cuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cuw ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cuw OCA], [http://pdbe.org/5cuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cuw RCSB], [http://www.ebi.ac.uk/pdbsum/5cuw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cuw ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/SRTE1_STRCO SRTE1_STRCO] Transpeptidase that anchors surface proteins to the cell wall. Recognizes both Leu-Ala-x-Thr-Gly and Leu-Pro-x-Thr-Gly, with a preference for the former. Unlike the S.aureus sortase it cleaves not only the Thr-Gly motif but also the Ala-X bond; Ala-Glu and Ala-His bonds are better substrates than the Thr-Gly motif in vitro (PubMed:22296345, PubMed:27936128). Among its possible substrates are the chaplins ChpA, ChpB and ChpC; this enzyme is less important for ChpC attachment than is SrtE2. A double knockout mutant of srtE1 and srtE2 shows a developmental defect in aerial hyphae formation more dramatic than that due to chaplin deletion (PubMed:22296345).<ref>PMID:22296345</ref> <ref>PMID:27936128</ref>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Strco]]
+[[Category: Cascio D]]
-[[Category: Cascio, D]]
+[[Category: Clubb RT]]
-[[Category: Clubb, R T]]
+[[Category: Kattke MD]]
-[[Category: Kattke, M D]]
+[[Category: Sawaya MR]]
-[[Category: Sawaya, M R]]
-[[Category: Aminoacyltransferase]]
-[[Category: Bacterial protein]]
-[[Category: Beta barrel]]
-[[Category: Catalytic domain]]
-[[Category: Class e]]
-[[Category: Cysteine endopeptidase]]
-[[Category: Membrane protein]]
-[[Category: Protein binding]]
-[[Category: Sortase]]
-[[Category: Srte]]
-[[Category: Transpeptidase]]