8oig: Difference between revisions
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==Crystal Structure of Staphopain C from Staphylococcus aureus== | |||
<StructureSection load='8oig' size='340' side='right'caption='[[8oig]], [[Resolution|resolution]] 1.58Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8oig]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OIG FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oig OCA], [https://pdbe.org/8oig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oig RCSB], [https://www.ebi.ac.uk/pdbsum/8oig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oig ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q8RJP3_STAAU Q8RJP3_STAAU] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Staphylococcus aureus is a common opportunistic pathogen of humans and livestock that causes a wide variety of infections. The success of S. aureus as a pathogen depends on the production of an array of virulence factors including cysteine proteases (staphopains)-major secreted proteases of certain strains of the bacterium. Here, we report the three-dimensional structure of staphopain C (ScpA2) of S. aureus, which shows the typical papain-like fold and uncovers a detailed molecular description of the active site. Because the protein is involved in the pathogenesis of a chicken disease, our work provides the foundation for inhibitor design and potential antimicrobial strategies against this pathogen. | |||
Crystal Structure of Staphopain C from Staphylococcus aureus.,Magoch M, McEwen AG, Napolitano V, Wladyka B, Dubin G Molecules. 2023 May 29;28(11):4407. doi: 10.3390/molecules28114407. PMID:37298883<ref>PMID:37298883</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 8oig" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus]] | |||
[[Category: Dubin G]] | |||
[[Category: Magoch M]] | |||
[[Category: McEwen AG]] | |||
[[Category: Napolitano V]] | |||
[[Category: Wladyka B]] | |||
Revision as of 09:42, 21 June 2023
Crystal Structure of Staphopain C from Staphylococcus aureus
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