7kxs: Difference between revisions
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==Computational design of constitutively active cGAS== | ==Computational design of constitutively active cGAS== | ||
<StructureSection load='7kxs' size='340' side='right'caption='[[7kxs]]' scene=''> | <StructureSection load='7kxs' size='340' side='right'caption='[[7kxs]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KXS FirstGlance]. <br> | <table><tr><td colspan='2'>[[7kxs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KXS FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kxs OCA], [https://pdbe.org/7kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kxs RCSB], [https://www.ebi.ac.uk/pdbsum/7kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kxs ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kxs OCA], [https://pdbe.org/7kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kxs RCSB], [https://www.ebi.ac.uk/pdbsum/7kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kxs ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. | |||
==See Also== | |||
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | |||
[[Category: Bera AK]] | [[Category: Bera AK]] | ||
[[Category: Bick M]] | [[Category: Bick M]] | ||
Revision as of 09:44, 21 June 2023
Computational design of constitutively active cGAS
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