5cw3: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:


==Structure of CfBRCC36-CfKIAA0157 complex (Zn Edge)==
==Structure of CfBRCC36-CfKIAA0157 complex (Zn Edge)==
<StructureSection load='5cw3' size='340' side='right' caption='[[5cw3]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='5cw3' size='340' side='right'caption='[[5cw3]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5cw3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camfo Camfo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CW3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5cw3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camponotus_floridanus Camponotus floridanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CW3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cw6|5cw6]], [[5cw5|5cw5]], [[5cw4|5cw4]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cw3 OCA], [https://pdbe.org/5cw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cw3 RCSB], [https://www.ebi.ac.uk/pdbsum/5cw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cw3 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EAG_15736 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=104421 CAMFO]), EAG_01033 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=104421 CAMFO])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cw3 OCA], [http://pdbe.org/5cw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cw3 RCSB], [http://www.ebi.ac.uk/pdbsum/5cw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cw3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BRCC3_CAMFO BRCC3_CAMFO] Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, leaving the last ubiquitin chain attached to its substrates. Catalytic subunit of the BRISC complex; does not have activity by itself, but needs to be associated into a heterotetramer with ABRAXAS2 for minimal in vitro activity (PubMed:26344097). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating spindle assembly factors (By similarity).[UniProtKB:Q15018][UniProtKB:Q3TCJ1]<ref>PMID:26344097</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 22:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Camfo]]
[[Category: Camponotus floridanus]]
[[Category: Zeqiraj, E]]
[[Category: Large Structures]]
[[Category: Metal binding protein]]
[[Category: Zeqiraj E]]
[[Category: Metal dependent enzyme]]
Retrieved from "https://proteopedia.org/5cw3"