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<StructureSection load='5czv' size='340' side='right'caption='[[5czv]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
<StructureSection load='5czv' size='340' side='right'caption='[[5czv]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5czv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CZV FirstGlance]. <br>
<table><tr><td colspan='2'>[[5czv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CZV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5czx|5czx]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5czv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5czv OCA], [https://pdbe.org/5czv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5czv RCSB], [https://www.ebi.ac.uk/pdbsum/5czv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5czv ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NOTCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5czv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5czv OCA], [http://pdbe.org/5czv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5czv RCSB], [http://www.ebi.ac.uk/pdbsum/5czv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5czv ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/NOTC3_HUMAN NOTC3_HUMAN]] CADASIL;Infantile myofibromatosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/NOTC3_HUMAN NOTC3_HUMAN] CADASIL;Infantile myofibromatosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NOTC3_HUMAN NOTC3_HUMAN]] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).  
[https://www.uniprot.org/uniprot/NOTC3_HUMAN NOTC3_HUMAN] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chopra, R]]
[[Category: Chopra R]]
[[Category: Clark, K]]
[[Category: Clark K]]
[[Category: Fryer, C]]
[[Category: Fryer C]]
[[Category: Hu, T]]
[[Category: Hu T]]
[[Category: Antibody]]
[[Category: Immune system]]
[[Category: Notch3]]
[[Category: Oncology]]
Retrieved from "https://proteopedia.org/5czv"