5d9a: Difference between revisions

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<StructureSection load='5d9a' size='340' side='right'caption='[[5d9a]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
<StructureSection load='5d9a' size='340' side='right'caption='[[5d9a]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5d9a]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Incjh Incjh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D9A FirstGlance]. <br>
<table><tr><td colspan='2'>[[5d9a]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_C_virus_(C/Johannesburg/1/66) Influenza C virus (C/Johannesburg/1/66)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D9A FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d98|5d98]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9a OCA], [https://pdbe.org/5d9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d9a RCSB], [https://www.ebi.ac.uk/pdbsum/5d9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9a ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA, P3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=100673 INCJH]), PB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=100673 INCJH]), PB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=100673 INCJH])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9a OCA], [http://pdbe.org/5d9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d9a RCSB], [http://www.ebi.ac.uk/pdbsum/5d9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PA_INCJH PA_INCJH]] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication (By similarity). [[http://www.uniprot.org/uniprot/PB2_INCJH PB2_INCJH]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1 (By similarity). [[http://www.uniprot.org/uniprot/RDRP_INCJH RDRP_INCJH]] RNA-dependent RNA polymerase which is responsible for replication and transcription of virus segments. Binds the promoter sequence of the encapsidated viral RNA. Displays an endonuclease activity involved in cap-stealing. Cleaves cellular pre-mRNA to generate primers for viral transcription (By similarity).  
[https://www.uniprot.org/uniprot/PA_INCJH PA_INCJH] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[RNA polymerase|RNA polymerase]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Incjh]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Bricogne G]]
[[Category: Bricogne, G]]
[[Category: Cusack S]]
[[Category: Cusack, S]]
[[Category: El Omari K]]
[[Category: Fodor, E]]
[[Category: Fodor E]]
[[Category: Grimes, J M]]
[[Category: Grimes JM]]
[[Category: Hengrung, N]]
[[Category: Hengrung N]]
[[Category: Martin, I Serna]]
[[Category: Rambo RP]]
[[Category: Omari, K El]]
[[Category: Serna Martin I]]
[[Category: Rambo, R P]]
[[Category: Stuart DI]]
[[Category: Stuart, D I]]
[[Category: Vonrhein C]]
[[Category: Vonrhein, C]]
[[Category: Vreede FT]]
[[Category: Vreede, F T]]
[[Category: Influenza]]
[[Category: Influenza c virus]]
[[Category: Negative-strand virus]]
[[Category: Rna-dependent rna polymerase]]
[[Category: Viral protein]]
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