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'''Unreleased structure'''


The entry 8jo0 is ON HOLD
==The Cryo-EM structure of a heptameric CED-4/CED-3 catalytic complex==
 
<StructureSection load='8jo0' size='340' side='right'caption='[[8jo0]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
Authors: Yini, L., Yigong, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8jo0]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JO0 FirstGlance]. <br>
Description: The Cryo-EM structure of a heptameric CED-4/CED-3 catalytic complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Yigong, S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jo0 OCA], [https://pdbe.org/8jo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jo0 RCSB], [https://www.ebi.ac.uk/pdbsum/8jo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jo0 ProSAT]</span></td></tr>
[[Category: Yini, L]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/CED4_CAEEL CED4_CAEEL] Isoform a plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Isoform b prevents PCD.<ref>PMID:1286611</ref> <ref>PMID:8706125</ref> <ref>PMID:9027313</ref> <ref>PMID:10688797</ref> <ref>PMID:15383288</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Li Y]]
[[Category: Shi Y]]
Retrieved from "https://proteopedia.org/8jo0"