5dil: Difference between revisions

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<StructureSection load='5dil' size='340' side='right'caption='[[5dil]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='5dil' size='340' side='right'caption='[[5dil]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5dil]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/singapore/dso_090134/2004) Influenza b virus (b/singapore/dso_090134/2004)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DIL FirstGlance]. <br>
<table><tr><td colspan='2'>[[5dil]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Singapore/DSO_090134/2004) Influenza B virus (B/Singapore/DSO_090134/2004)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DIL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=741218 Influenza B virus (B/Singapore/DSO_090134/2004)])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dil OCA], [https://pdbe.org/5dil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dil RCSB], [https://www.ebi.ac.uk/pdbsum/5dil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dil ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dil OCA], [http://pdbe.org/5dil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dil RCSB], [http://www.ebi.ac.uk/pdbsum/5dil PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dil ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/X2C382_9INFB X2C382_9INFB]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[PIRNR:PIRNR003938]  
[https://www.uniprot.org/uniprot/X2C382_9INFB X2C382_9INFB] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.[PIRNR:PIRNR003938]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Guan, R]]
[[Category: Guan R]]
[[Category: Hamilton, K]]
[[Category: Hamilton K]]
[[Category: Ma, L]]
[[Category: Ma L]]
[[Category: Montelione, G T]]
[[Category: Montelione GT]]
[[Category: Effector domain]]
[[Category: Rna binding]]
[[Category: Rna-binding protein]]
[[Category: Viral protein]]
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