5do2: Difference between revisions
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<StructureSection load='5do2' size='340' side='right'caption='[[5do2]], [[Resolution|resolution]] 2.41Å' scene=''> | <StructureSection load='5do2' size='340' side='right'caption='[[5do2]], [[Resolution|resolution]] 2.41Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5do2]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5do2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DO2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.409Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5do2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5do2 OCA], [https://pdbe.org/5do2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5do2 RCSB], [https://www.ebi.ac.uk/pdbsum/5do2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5do2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/K0BRG7_MERS K0BRG7_MERS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5do2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5do2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Sandbox 3001|Sandbox 3001]] | |||
*[[Spike protein|Spike protein]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Middle East respiratory syndrome-related coronavirus]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Gao | [[Category: Gao GF]] | ||
[[Category: Li | [[Category: Li Y]] | ||
[[Category: Liu | [[Category: Liu P]] | ||
[[Category: Liu | [[Category: Liu W]] | ||
[[Category: Lu | [[Category: Lu G]] | ||
[[Category: Lu | [[Category: Lu X]] | ||
[[Category: Perlman | [[Category: Perlman S]] | ||
[[Category: Qi | [[Category: Qi J]] | ||
[[Category: Wan | [[Category: Wan Y]] | ||
[[Category: Wang | [[Category: Wang Q]] | ||
[[Category: Wu | [[Category: Wu Y]] | ||
[[Category: Yan | [[Category: Yan J]] | ||
[[Category: Yuen | [[Category: Yuen KY]] | ||
[[Category: Zhao | [[Category: Zhao J]] | ||
