8t55: Difference between revisions

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'''Unreleased structure'''


The entry 8t55 is ON HOLD
==Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654==
 
<StructureSection load='8t55' size='340' side='right'caption='[[8t55]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
Authors: Ahmad, H., Zeng, H., Dong, A., Li, Y., Yen, H., Seitova, A., Xu, J., Feng, J.W., Brown, P.J., Santhakumar, V., Ackloo, S., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8t55]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T55 FirstGlance]. <br>
Description: Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZI3:N-[3-(4-chlorophenyl)oxetan-3-yl]-1-propanoyl-1,2,3,4-tetrahydroquinoline-5-carboxamide'>ZI3</scene></td></tr>
[[Category: Dong, A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t55 OCA], [https://pdbe.org/8t55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t55 RCSB], [https://www.ebi.ac.uk/pdbsum/8t55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t55 ProSAT]</span></td></tr>
[[Category: Li, Y]]
</table>
[[Category: Halabelian, L]]
== Function ==
[[Category: Feng, J.W]]
[https://www.uniprot.org/uniprot/WDR91_HUMAN WDR91_HUMAN] Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB:Q7TMQ7]<ref>PMID:26783301</ref> <ref>PMID:27126989</ref>
[[Category: Zeng, H]]
== References ==
[[Category: Arrowsmith, C.H]]
<references/>
[[Category: Santhakumar, V]]
__TOC__
[[Category: Seitova, A]]
</StructureSection>
[[Category: Yen, H]]
[[Category: Homo sapiens]]
[[Category: Brown, P.J]]
[[Category: Large Structures]]
[[Category: Ackloo, S]]
[[Category: Ackloo S]]
[[Category: Edwards, A.M]]
[[Category: Ahmad H]]
[[Category: Xu, J]]
[[Category: Arrowsmith CH]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Brown PJ]]
[[Category: Ahmad, H]]
[[Category: Dong A]]
[[Category: Edwards AM]]
[[Category: Feng JW]]
[[Category: Halabelian L]]
[[Category: Li Y]]
[[Category: Santhakumar V]]
[[Category: Seitova A]]
[[Category: Xu J]]
[[Category: Yen H]]
[[Category: Zeng H]]
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