7stx: Difference between revisions
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==== | ==Cryo-EM structure of human NatB in complex with CoA-Alpha-Synuclein== | ||
<StructureSection load='7stx' size='340' side='right'caption='[[7stx]]' scene=''> | <StructureSection load='7stx' size='340' side='right'caption='[[7stx]], [[Resolution|resolution]] 3.14Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7stx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STX FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stx OCA], [https://pdbe.org/7stx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stx RCSB], [https://www.ebi.ac.uk/pdbsum/7stx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stx ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.14Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stx OCA], [https://pdbe.org/7stx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stx RCSB], [https://www.ebi.ac.uk/pdbsum/7stx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stx ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/NAA20_HUMAN NAA20_HUMAN] Autosomal recessive non-syndromic intellectual disability. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NAA20_HUMAN NAA20_HUMAN] Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln (PubMed:34230638). Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.<ref>PMID:18570629</ref> <ref>PMID:34230638</ref> | |||
==See Also== | |||
*[[Alpha-synuclein|Alpha-synuclein]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Deng S]] | ||
[[Category: Marmorstein R]] | |||
Latest revision as of 05:50, 5 July 2023
Cryo-EM structure of human NatB in complex with CoA-Alpha-Synuclein
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