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==STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS==
==STRUCTURE-ACTIVITY RELATIONSHIPS OF MU-CONOTOXIN GIIIA: STRUCTURE DETERMINATION OF ACTIVE AND INACTIVE SODIUM CHANNEL BLOCKER PEPTIDES BY NMR AND SIMULATED ANNEALING CALCULATIONS==
<StructureSection load='1tck' size='340' side='right'caption='[[1tck]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='1tck' size='340' side='right'caption='[[1tck]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1tck]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conge Conge]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TCK FirstGlance]. <br>
<table><tr><td colspan='2'>[[1tck]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TCK FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tch|1tch]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tck OCA], [https://pdbe.org/1tck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tck RCSB], [https://www.ebi.ac.uk/pdbsum/1tck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tck ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tck OCA], [https://pdbe.org/1tck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tck RCSB], [https://www.ebi.ac.uk/pdbsum/1tck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tck ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CM3A_CONGE CM3A_CONGE]] Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks Nav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, and mNav1.6/SCN8A. The inhibition is reversible. Induces paralysis in vertebrates.<ref>PMID:18950653</ref> <ref>PMID:21652775</ref> <ref>PMID:2410412</ref>
[https://www.uniprot.org/uniprot/CM3A_CONGE CM3A_CONGE] Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks Nav1.4/SCN4A. It also moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, and mNav1.6/SCN8A. The inhibition is reversible. Induces paralysis in vertebrates.<ref>PMID:18950653</ref> <ref>PMID:21652775</ref> <ref>PMID:2410412</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Conge]]
[[Category: Conus geographus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Inagaki, F]]
[[Category: Inagaki F]]
[[Category: Kohda, D]]
[[Category: Kohda D]]
[[Category: Lancelin, J M]]
[[Category: Lancelin J-M]]
[[Category: Neurotoxin]]
Retrieved from "https://proteopedia.org/1tck"