5eap: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 1: Line 1:


==Crystal structure of human WDR5 in complex with compound 9e==
==Crystal structure of human WDR5 in complex with compound 9e==
<StructureSection load='5eap' size='340' side='right' caption='[[5eap]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
<StructureSection load='5eap' size='340' side='right'caption='[[5eap]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5eap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EAP FirstGlance]. <br>
<table><tr><td colspan='2'>[[5eap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EAP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5MO:N-[5-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)-2-(4-METHYLPIPERAZIN-1-YL)PHENYL]-3-METHYLBENZAMIDE'>5MO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eal|5eal]], [[5eam|5eam]], [[5ear|5ear]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5MO:N-[5-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)-2-(4-METHYLPIPERAZIN-1-YL)PHENYL]-3-METHYLBENZAMIDE'>5MO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eap OCA], [https://pdbe.org/5eap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eap RCSB], [https://www.ebi.ac.uk/pdbsum/5eap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eap ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eap OCA], [http://pdbe.org/5eap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eap RCSB], [http://www.ebi.ac.uk/pdbsum/5eap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eap ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 21:


==See Also==
==See Also==
*[[WD repeat-containing protein|WD repeat-containing protein]]
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: AL-AWAR, R]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: AL-AWAR R]]
[[Category: BOLSHAN, Y]]
[[Category: Arrowsmith CH]]
[[Category: BROWN, P J]]
[[Category: BOLSHAN Y]]
[[Category: Bountra, C]]
[[Category: BROWN PJ]]
[[Category: DOMBROVSKI, L]]
[[Category: Bountra C]]
[[Category: DONG, A]]
[[Category: DOMBROVSKI L]]
[[Category: Edwards, A M]]
[[Category: DONG A]]
[[Category: GETLIK, M]]
[[Category: Edwards AM]]
[[Category: PODA, G]]
[[Category: GETLIK M]]
[[Category: SCHAPIRA, M]]
[[Category: PODA G]]
[[Category: SENISTERRA, G]]
[[Category: SCHAPIRA M]]
[[Category: Structural genomic]]
[[Category: SENISTERRA G]]
[[Category: SMIL, D]]
[[Category: SMIL D]]
[[Category: VEDADI, M]]
[[Category: VEDADI M]]
[[Category: WALKER, J R]]
[[Category: WALKER JR]]
[[Category: WU, H]]
[[Category: WU H]]
[[Category: Compound 9e]]
[[Category: Sgc]]
[[Category: Transcription-transcription inhibitor complex]]
[[Category: Wdr5]]
Retrieved from "https://proteopedia.org/5eap"