8cjv: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8cjv is ~~ON HOLD until Paper Publication~~

==Structure of bovine CD46 ectodomain (SCR 1-4)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8cjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CJV OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8CJV FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8cjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cjv OCA], [https://pdbe.org/8cjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cjv RCSB], [https://www.ebi.ac.uk/pdbsum/8cjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cjv ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/MCP_BOVIN MCP_BOVIN] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells.

__TOC__

</StructureSection>

[[Category: Bos taurus]]

[[Category: Large Structures]]

[[Category: Aitkenhead H]]

[[Category: El Omari K]]

[[Category: Stuart DI]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8cjv is ON HOLD  until Paper Publication
+==Structure of bovine CD46 ectodomain (SCR 1-4)==
+<StructureSection load='8cjv' size='340' side='right'caption='[[8cjv]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8cjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CJV FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cjv OCA], [https://pdbe.org/8cjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cjv RCSB], [https://www.ebi.ac.uk/pdbsum/8cjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cjv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MCP_BOVIN MCP_BOVIN] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells.
+__TOC__
+</StructureSection>
+[[Category: Bos taurus]]
+[[Category: Large Structures]]
+[[Category: Aitkenhead H]]
+[[Category: El Omari K]]
+[[Category: Stuart DI]]